p6con 由 N Azuma 著作 · 1999 · 被引用 150 次 — In the present study, the V54D mutation mildly increased P6CON-binding activity and decreased transactivation via 5aCON, a result that also fits with this model ...
由 Y Yamaguchi 著作 1997 被引用 50 次 According to this model NTS is involved in the P6CON binding and the 5a insertion serves as a molecular switch to unmask the cryptic DNA binding activity of 由 BK Chauhan 著作 2004 被引用 84 次 PAX6 activated transcription from P6CON while PAX6 5a had barely any positive effect However the combination of PAX6 and PAX6 5a expression generated Pax6 is a key regulatory gene for eye brain and pancreas development It acts as a transcriptional activator and repressor Loss of function of Pax6 results 由 S Singh 著作 2000 被引用 62 次 As expected PAX6 bound to all the binding sites with high affinity whereas the mutants R26G and I87R bound to only P6CON and with much lower affinity 由 Q Xie 著作 2014 被引用 26 次 Pax6 is a key regulatory gene for eye brain and pancreas development It acts as a transcriptional activator and repressor
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Impaired DNA-binding affinity of novel PAX6 mutations
Reviewed in the Thailand on July 6, 2025
由 S Lee 著作 · 2020 · 被引用 13 次 — Since P6B and P6CON have similar DNA sequence to be recognized by PAX6, effects caused by PAX6 mutation could be quite similar to each other ( ...
Autoregulation of Pax6 transcriptional activation by two ...
Reviewed in the Thailand on July 17, 2025
由 N Azuma 著作 · 1999 · 被引用 150 次 — In the present study, the V54D mutation mildly increased P6CON-binding activity and decreased transactivation via 5aCON, a result that also fits with this model ...
Transcriptional regulation by PAX6 and PAX6(5a) on ...
Reviewed in the Thailand on June 25, 2025
由 N Azuma 著作 · 1999 · 被引用 150 次 — In the present study, the V54D mutation mildly increased P6CON-binding activity and decreased transactivation via 5aCON, a result that also fits with this model ...
